Detailed view for EgrG_000134100

Basic information

TDR Targets ID: 594824
Echinococcus granulosus, transient receptor potential cation channel
Source Database / ID:  GeneDB

pI: 9.3735 | Length (AA): 531 | MW (Da): 60442 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 2

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
225 338 5n9g (F) 89 188 32.00 0.86 0.29 0.290689 0.86

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128054)

Species Accession Gene Product
Brugia malayi Bm1_48840   cation channel family protein
Brugia malayi Bm1_00480   hypothetical protein
Caenorhabditis elegans CELE_C05C12.3   Protein GTL-1
Caenorhabditis elegans CELE_F54D1.5   Protein GTL-2
Caenorhabditis elegans CELE_T01H8.5   Protein GON-2, isoform E
Drosophila melanogaster Dmel_CG44240   Transient receptor potential cation channel, subfamily M ortholog
Echinococcus granulosus EgrG_000589600   transient receptor potential cation channel
Echinococcus granulosus EgrG_000134100   transient receptor potential cation channel
Echinococcus granulosus EgrG_000175000   transient receptor potential cation channel
Echinococcus multilocularis EmuJ_000175000   transient receptor potential cation channel
Echinococcus multilocularis EmuJ_000134100   transient receptor potential cation channel
Echinococcus multilocularis EmuJ_000589600   transient receptor potential cation channel
Homo sapiens ENSG00000083067   transient receptor potential cation channel, subfamily M, member 3
Homo sapiens ENSG00000092439   transient receptor potential cation channel, subfamily M, member 7
Homo sapiens ENSG00000119121   transient receptor potential cation channel, subfamily M, member 6
Homo sapiens ENSG00000134160   transient receptor potential cation channel, subfamily M, member 1
Loa Loa (eye worm) LOAG_06724   hypothetical protein
Loa Loa (eye worm) LOAG_10858   hypothetical protein
Loa Loa (eye worm) LOAG_07783   hypothetical protein
Mus musculus ENSMUSG00000027365   transient receptor potential cation channel, subfamily M, member 7
Mus musculus ENSMUSG00000030523   transient receptor potential cation channel, subfamily M, member 1
Mus musculus ENSMUSG00000024727   transient receptor potential cation channel, subfamily M, member 6
Mus musculus ENSMUSG00000052387   transient receptor potential cation channel, subfamily M, member 3
Onchocerca volvulus OVOC1481   Transient receptor potential cation channel trpm homolog
Onchocerca volvulus OVOC1219   Transient receptor potential cation channel subfamily M member 8 homolog
Onchocerca volvulus OVOC805  
Onchocerca volvulus OVOC1478   Transient receptor potential cation channel trpm homolog
Schistosoma japonicum Sjp_0042610   ko:K05392 transient receptor potential cation channel, subfamily M,, putative
Schistosoma japonicum Sjp_0011270   ko:K04978 transient receptor potential cation channel, subfamily M, member 3, putative
Schistosoma japonicum Sjp_0011300   Transient receptor potential cation channel subfamily M member 1, putative
Schistosoma japonicum Sjp_0116790   Transient receptor potential cation channel subfamily M member 7, putative
Schistosoma japonicum Sjp_0129220   Transient receptor potential channel, putative
Schistosoma japonicum Sjp_0022790   ko:K04982 transient receptor potential cation channel, subfamily M, member 7, putative
Schistosoma mansoni Smp_147140   transient receptor potential cation channel subfamily m member
Schistosoma mansoni Smp_173720   transient receptor potential cation channel subfamily m member
Schistosoma mansoni Smp_165170   transient receptor potential cation channel subfamily m member
Schmidtea mediterranea mk4.002702.06  
Schmidtea mediterranea mk4.003995.01  
Schmidtea mediterranea mk4.003423.05  
Schmidtea mediterranea mk4.009767.02  
Schmidtea mediterranea mk4.002702.03  
Schmidtea mediterranea mk4.012002.01  
Schmidtea mediterranea mk4.003423.09  
Schmidtea mediterranea mk4.001809.09  
Schmidtea mediterranea mk4.062863.00   Transient receptor potential cation channel trpm
Schmidtea mediterranea mk4.014768.00   Putative transient receptor potential cation channel
Schmidtea mediterranea mk4.002605.00  
Schmidtea mediterranea mk4.001809.07  
Schmidtea mediterranea mk4.001194.08  
Schmidtea mediterranea mk4.003042.02  
Schmidtea mediterranea mk4.003995.02  
Schmidtea mediterranea mk4.005771.01  
Schmidtea mediterranea mk4.001194.06  
Schmidtea mediterranea mk4.003995.04  
Schmidtea mediterranea mk4.001809.06  
Schmidtea mediterranea mk4.003628.01   Transient receptor potential cation channel,putative
Schmidtea mediterranea mk4.032773.00  
Schmidtea mediterranea mk4.002702.05  

Essentiality

EgrG_000134100 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_C05C12.3 Caenorhabditis elegans larval arrest wormbase
CELE_C05C12.3 Caenorhabditis elegans slow growth wormbase
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens transient receptor potential cation channel, subfamily M, member 6 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EgrG_000134100 (Echinococcus granulosus), transient receptor potential cation channel
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